Correlation between FMR1 CGG Repeat Sizes in the High Normal Range and Idiopathic Premature Ovarian Failure in Hong Kong Chinese Women

Abstract

Objective: The aim of this study was to examine the relationship between FMR1 gene CGG repeat sizes in the high normal range and risk of premature ovarian failure in a Hong Kong Chinese population.
Methods: In this retrospective study, the FMR1 gene CGG repeat sizes of women with idiopathic premature ovarian failure and control participants were determined. The control participants were healthy mothers of children with denovo genetic conditions. Correlation study analysis was performed to test for the relationship between FMR1 gene CGG repeat sizes in the high normal range and idiopathic premature ovarian failure.
Results: A total of 196 and 204 women were included in the idiopathic premature ovarian failure and control groups, respectively. The mean ages of menopause in the women with all causes of premature ovarian failure and women with idiopathic premature ovarian failure were the same at 27.7 years. Correlation study analysis showed no correlation between FMR1 gene CGG repeat sizes in the high normal range and idiopathic premature ovarian failure in this population.
Conclusion: This study showed no correlation between FMR1 gene CGG repeat sizes in the high normal range and idiopathic premature ovarian failure in this population. The results confirm the characteristic bimodal distribution of CGG repeat sizes shown in previous studies in Chinese populations.