Comparison of Ongoing Pregnancy Rates and Multiple Pregnancy Rates of Intrauterine Insemination with Ovarian Stimulation Using Clomiphene Citrate Versus Gonadotrophin Protocols

Abstract

Objective: To compare the ongoing pregnancy rates and the multiple pregnancy rates of intrauterine insemination with ovarian stimulation using clomiphene citrate versus gonadotrophin protocols.
Methods: Retrospective cohort study.
Results: There were no statistically significant differences in the ongoing pregnancy rate and multiple pregnancy rate of intrauterine insemination following ovarian stimulation by clomiphene citrate and gonadotrophins. In the gonadotrophin group, eight patients had multiple pregnancies (seven had twins and one had triplets) while no subject in the clomiphene citrate group had multiple pregnancy.
Conclusion: The ongoing pregnancy rate with intrauterine insemination using clomiphene citrate stimulation was comparable to that using gonadotrophin stimulation. Intrauterine insemination with clomiphene citrate stimulation may be associated with a lower chance of multiple pregnancies when compared with gonadotrophin stimulation. Clomiphene citrate is a cheaper alternative to gonadotrophins in intrauterine insemination treatment.