Predictors for adverse outcomes in pregnant women with COVID-19 infection: a retrospective study
DOI:
https://doi.org/10.12809/hkjgom.24.1.377Keywords:
COVID-19, Pregnancy outcome, VaccinationAbstract
Objective: We aimed to identify predictors associated with adverse maternal and neonatal outcomes in women with COVID-19 infection.
Methods: Medical records of women with a singleton pregnancy who were diagnosed with COVID-19 infection at any gestational age and delivered in Tuen Mun Hospital between 1 January 2022 and 31 December 2022 were retrospectively reviewed. Pregnant women with COVID-19 infection who had or had no composite adverse outcomes were compared. Risk factors associated with COVID-19 disease severity and maternal and neonatal outcomes were determined.
Results: In total, 233 pregnant women were included in the analysis. Women with composite adverse outcomes from COVID-19 infection were more likely to have advanced maternal age (adjusted odds ratio [aOR]=4.19, p=0.013) and no prior COVID-19 vaccination (aOR=0.27, p=0.019). Women with composite adverse maternal outcomes were more likely to have advanced maternal age (aOR=2.25, p=0.009), an abnormal body mass index (aOR=1.76, p=0.040), and active COVID-19 infection at the time of delivery (aOR=1.81, p=0.045). Neonates with composite adverse outcomes were more likely to have been born to mothers with comorbidities (aOR=3.13, p=0.007).
Conclusion: Risk factors for severe COVID-19 disease and adverse maternal and neonatal outcomes include advanced maternal age, pre-existing comorbidities, abnormal BMI, active COVID-19 infection at delivery, and no prior COVID-19 vaccination.
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